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第一部分 奋斗历程1

走近顾健人3

第二部分 学术贡献27

一、顾健人院士的学术成就与学术思想29

顾健人院士的学术贡献29

二、顾健人院士主要学术论文37

（一）肿瘤分子生物学（癌基因谱）（1985—1988年）37

从乙型肝炎病毒表面抗原阳性母亲流产的胎儿查出乙型肝炎病毒标志37

人原发性肝癌及7402细胞株和髓细胞白血病细胞株（K562）的癌基因（转化基因）的共同属性——N-ras基因43

Molecular Aspects of Human Hepatic Carcinogenesis49

（二）肝癌的基因异常与缺陷（1993—2003年）59

Aberrations of p53 Gene in Human Hepatocellular Carcinoma From China59

Hepatitis B Virus X Protein Inhibits p53 Sequence-specific DNA Binding,Transcriptional Activity,and Association with Transcription Factor ERCC368

A Novel Growth Suppressor Gene on Chromosome 17p13.3 with a High Frequency of Mutation in Human Hepatocellular Carcinoma76

Cloning and Characterization of a Novel Gene（C17orf25）from the Deletion Region on Chromosome 17p13.3 in Hepatocelular Carcinoma83

Allelic Loss and Gain,But Not Genomic Instability,as the Major Somatic Mutation in Primary Hepatocellular Carcinoma91

Cloning,Mapping,and Characterization of a Human Homologue of the Yeast Longevity Assurance Gene LAG199

The Minimum LOH Region Defined on Chromosome 17p13.3 in Human Hepatocellular Carcinoma with Gene Content Analysis107

（三）肿瘤整合生物学与系统调控（2004—）118

Large-scale cDNA Transfection Screening for Genes Related to Cancer Development and Progression118

The Growth and Metastasis of Human Hepatocellular Carcinoma Xenografts Are Inhibited by Small Interfering RNA Targeting to the Subunit ATP6L of Proton Pump128

Identification and Characterization of a Novel Peptide Ligand of Epidermal Growth Factor Receptor for Targeted Delivery of Therapeutics138

Identification of Carboxypeptidase of Glutamate Like-B as a Candidate Suppressor in Cell Growth and Metastasis in Human Hepatocellular Carcinoma149

Ex vivo Nicotine Stimulation Augments the Efficacy of Therapeutic Bone Marrow-Derived Dendritic Cell Vaccination160

CD133 Positive Hepatocellular Carcinoma Cells Possess High Capacity for Tumorigenicity169

Analysis of ABCG2 Expression and Side Population Identifies Intrinsic Drug Efflux in the HCC Cell Line MHCC-97L and its Modulation by Akt Signaling179

Dysfunction of Murine Dendritic Cells Induced by Incubation with Tumor Cells192

Ciliary Neurotrophic Factor Receptor α Subunit-Modulated Multiple Downstream Signaling Pathways in Hepatic Cancer Cell Lines and Their Biological Implications202

Diagnostic and Prognostic Implications of microRNAs in Human Hepatocellular Carcinoma214

Elevated Expression of DKK1 is Associated With Cytoplasmic/Nuclear β-catenin Accumulation and Poor Prognosis in Hepatocellular Carcinomas225

MicroRNA-30d Promotes Tumor Invasion and Metastasis by Targeting Galphai2 in Hepatocellular Carcinoma236

Dickkopf-1 Autoantibody is a Novel Serological Biomarker for Non-small Cell Lung Cancer247

Cancer stem/progenitor Cells are Highly Enriched in CD133+CD44+Population in Hepatocellular Carcinoma255

Gain of miR-151 on Chromosome 8q24.3 Facilitates Tumour Cell Migration and Spreading Through Downregulating RhoGDIA268

Temporal Acquisition of Sequential Mutations in the Enhancer II and Basal Core Promoter of HBV in Individuals At High Risk for Hepatocellular Carcinoma281

Acetylcholinesterase,a Key Prognostic Predictor for Hepatocellular Carcinoma,Suppresses Cell Growth and Induces Chemosensitization291

Genome-Wide Copy Number Analyses Identified Novel Cancer Genes in Hepatocellular Carcinoma303

Nicotine Stimulated Dendritic Cells Could Achieve Anti-Tumor Effects in Mouse Lung and Liver Cancer314

Activation of Androgen Receptor Induces ID1 and Promotes Hepatocellular Carcinoma Cell Migration and Invasion323

Serum DKK1 as a Protein Biomarker for the Diagnosis of Hepatocellular Carcinoma：a Large scale,Multicentre Study333

Identification and Impact of Hepatitis B Virus DNA and Antigens in Pancreatic Cancer Tissues and Adiacent Non-cancerous Tissues346

Acetylcholine Acts on Androgen Receptor to Promote the Migration and Invasion but Inhibit the Apoptosis of Human Hepatocareinoma357

Monoamine Oxidase A Suppresses Hepatocellular Carcinoma Metastasis by Inhibiting the Adrenergic System and Its Transactivation of EGFR Signaling369

三、顾健人院士的主要学术著作381

基因治疗381

Primary Liver Cancer Challenges and Perspectives405

原发性肝癌——挑战与展望（译文）418

四、顾健人院士学术年表451

顾健人院士论文目录451

顾健人院士主要奖项目录493

顾健人院士主要荣誉495

顾健人院士主要学术任职497

第三部分 治学之道499

自述：求索之路——漫长、曲折和甘苦501

把握科学前沿的顾健人老师507

耕耘人生509

第四部分 大师风范515

我所尊敬的老师——顾健人院士517

山高水长 师恩难忘519

言传身教，师者楷模——我的恩师顾健人院士524

何为良师——向顾健人老师致敬526

引领——我所认识的顾健人院士528

我眼中的顾健人院士532

第五部分 社会影响535

德技双馨、真才实学的战略科学家537

一位真正的科学家541

最早关注与疾病相关基因的科学家543

学者、智者、师者的追求545

引领着我国癌基因研究的前沿548

我和顾健人先生是名副其实的忘年交550

顾健人：“人生当淡泊，求索无止境”554

第六部分 人生风采557

多彩人生559

学术活动563

国际交流566

成果荣誉569

领导关怀571

珍贵合影573